Differential neural mechanisms for early and late prediction error detection

Malekshahi, Rahim, Seth, Anil, Papanikolaou, Amalia, Mathews, Zenon, Birbaumer, Niels, Verschure, Paul F M J and Caria, Andrea (2016) Differential neural mechanisms for early and late prediction error detection. Nature: Scientific Reports, 6. a24350. ISSN 0028-0836

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Abstract

Emerging evidence indicates that prediction, instantiated at different perceptual levels, facilitate visual processing and enable prompt and appropriate reactions. Until now, the mechanisms underlying the effect of predictive coding at different stages of visual processing have still remained unclear. Here, we aimed to investigate early and late processing of spatial prediction violation by performing combined recordings of saccadic eye movements and fast event-related fMRI during a continuous visual detection task. Psychophysical reverse correlation analysis revealed that the degree of mismatch between current perceptual input and prior expectations is mainly processed at late rather than early stage, which is instead responsible for fast but general prediction error detection. Furthermore, our results suggest that conscious late detection of deviant stimuli is elicited by the assessment of prediction error’s extent more than by prediction error per se. Functional MRI and functional connectivity data analyses indicated that higher-level brain systems interactions modulate conscious detection of prediction error through top-down processes for the analysis of its representational content, and possibly regulate subsequent adaptation of predictivemodels. Overall, our experimental paradigm allowed to dissect explicit from implicit behavioral and neural responses to deviant stimuli in terms of their reliance on predictive models.

Item Type: Article
Schools and Departments: School of Engineering and Informatics > Informatics
Subjects: B Philosophy. Psychology. Religion > BF Psychology > BF0309 Consciousness. Cognition Including learning, attention, comprehension, memory, imagination, genius, intelligence, thought and thinking, psycholinguistics, mental fatigue
Depositing User: Marianne Cole
Date Deposited: 07 Apr 2016 08:29
Last Modified: 08 Mar 2017 05:24
URI: http://sro.sussex.ac.uk/id/eprint/60348

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