Depression phenotype, inflammation and the brain: implications for future research

Krishnadas, Rajeev and Harrison, Neil (2016) Depression phenotype, inflammation and the brain: implications for future research. Psychosomatic Medicine, 78 (4). pp. 384-388. ISSN 0033-3174

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Abstract

Inflammation is implicated in the etiology of Major Depressive Disorder (MDD). Human neuroimaging techniques are increasingly used to characterize the neural circuitry mediating actions of inflammation on mood, motivation and cognition and its relationship to MDD. In this issue, Byrne and colleagues report the first systematic review of these studies. The systematic review provides a much-needed synthesis of current research findings and highlights the role of cortical and subcortical brain structure and function. In this accompanying commentary, we highlight further points of particular relevance to future studies, including the potential advantages of functional phenotype models rather than the emphasis on mutually exclusive diagnostic categories in describing MDD and other psychiatric disorders. Novel imaging techniques will further enhance possibilities to clarify the link between inflammation and depression. New research challenges are described regarding the relationships between behavioural phenotype, brain structure and function, and peripheral inflammation.

Item Type: Article
Schools and Departments: Brighton and Sussex Medical School > Neuroscience
Subjects: R Medicine > RC Internal medicine > RC0321 Neurosciences. Biological psychiatry. Neuropsychiatry
Depositing User: Jonathan Williams
Date Deposited: 04 Apr 2016 14:50
Last Modified: 18 Jul 2017 21:32
URI: http://sro.sussex.ac.uk/id/eprint/60238

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