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Fluctuations in the open time of synaptic channels: an application to noise analysis based on charge
journal contribution
posted on 2023-06-09, 00:39 authored by Hinnerk Feldwisch-Drentrup, Adam BarrettAdam Barrett, Michael T Smith, Mark C W van RossumSynaptic channels are stochastic devices. Even recording from large ensembles of channels, the fluctuations, described by Markov transition matrices, can be used to extract single channel properties. Here we study fluctuations in the open time of channels, which is proportional to the charge flowing through the channel. We use the results to implement a novel type of noise analysis that uses the charge rather than the current to extract fundamental channel parameters. We show in simulations that this charge based noise analysis is more robust if the synapse is located on the dendrites and thus subject to cable filtering. However, we also demonstrate that when multiple synapses are distributed on the dendrites, noise analysis breaks down. We finally discuss applications of our results to other biological processes.
Funding
Towards a next-generation computational neuroscience; G0305; EPSRC-ENGINEERING & PHYSICAL SCIENCES RESEARCH COUNCIL; EP/G007543/1
History
Publication status
- Published
File Version
- Published version
Journal
Journal of Neuroscience MethodsISSN
0165-0270Publisher
ElsevierExternal DOI
Issue
1Volume
210Page range
15-21Department affiliated with
- Informatics Publications
Full text available
- No
Peer reviewed?
- Yes
Legacy Posted Date
2016-03-23First Compliant Deposit (FCD) Date
2016-03-23Usage metrics
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