Strategies in functional proteomics: unveiling the pathways to precision oncology

Favicchio, Rosy, Thepaut, Chloe, Zhang, Hua, Arends, Richard, Stebbing, Justin and Giamas, Georgios (2016) Strategies in functional proteomics: unveiling the pathways to precision oncology. Cancer Letters, 382 (1). pp. 86-94. ISSN 0304-3835

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Abstract

Personalised strategies in cancer care are required to overcome the therapeutic challenges posed by variability between patients and disease subsets. To this end, enhanced precision tools must be developed to describe the molecular drivers of malignant proliferation. Such tools must also identify druggable targets and biomarkers in order to provide essential information regarding drug development and therapeutic outcome. Here we discuss how proteomics-based approaches provide a set of viable methodologies capable of delivering quantitative information throughout the main stages of personalised oncology and a ratiometric platform that delivers systems-wide methods for drug evaluation.

Item Type: Article
Keywords: Personalised oncology; Therapeutics; Biomarkers; Cancer drivers; Drug development; Proteomics
Schools and Departments: School of Life Sciences > Biochemistry
Subjects: Q Science > Q Science (General)
Depositing User: Georgios Giamas
Date Deposited: 23 Feb 2016 08:41
Last Modified: 18 Nov 2016 12:51
URI: http://sro.sussex.ac.uk/id/eprint/59734
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