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Dementia of the eye: the role of amyloid beta in retinal degeneration

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journal contribution
posted on 2023-06-09, 00:13 authored by J A Ratnayaka, Louise SerpellLouise Serpell, A J Lotery
Age-related macular degeneration (AMD) is one of the most common causes of irreversible blindness affecting nearly 50 million individuals globally. The disease is characterised by progressive loss of central vision, which has significant implications for quality of life concerns in an increasingly ageing population. AMD pathology manifests in the macula, a specialised region of the retina, which is responsible for central vision and perception of fine details. The underlying pathology of this complex degenerative disease is incompletely understood but includes both genetic as well as epigenetic risk factors. The recent discovery that amyloid beta (Aß), a highly toxic and aggregate-prone family of peptides, is elevated in the ageing retina and is associated with AMD has opened up new perspectives on the aetiology of this debilitating blinding disease. Multiple studies now link Aß with key stages of AMD progression, which is both exciting and potentially insightful, as this identifies a well-established toxic agent that aggressively targets cells in degenerative brains. Here, we review the most recent findings supporting the hypothesis that Aß may be a key factor in AMD pathology. We describe how multiple Aß reservoirs, now reported in the ageing eye, may target the cellular physiology of the retina as well as associated layers, and propose a mechanistic pathway of Aß-mediated degenerative change leading to AMD.

History

Publication status

  • Published

File Version

  • Published version

Journal

Eye

ISSN

0950-222X

Publisher

Nature Publishing Group

Volume

29

Page range

1013-1026

Department affiliated with

  • Neuroscience Publications

Full text available

  • Yes

Peer reviewed?

  • Yes

Legacy Posted Date

2016-02-05

First Open Access (FOA) Date

2016-02-05

First Compliant Deposit (FCD) Date

2016-02-04

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