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Development and characterisation of sodium alginate and HPMC films for mucosal drug delivery

journal contribution
posted on 2023-06-09, 00:11 authored by Dinesh Rai, Mohammed Maniruzzaman, Joshua S. Boateng
The aim of this work was to develop and evaluate sodium alginate (SA) and hydroxypropyl methylcellulose (HPMC) films as novel drug delivery systems for moist surfaces such as wounds, buccal and vaginal cavities. Films containing SA or HPMC and PEG 200 or glycerol were prepared by a solvent casting technique. Process optimisation was performed to establish the best experimental parameters for preparing the films. Physical appearance, ease of removal, tensile properties (tensile strength, % strain at break) and plasticiser leaching were investigated. These criteria formed the basis for further development formulations comprising optimum ratios of SA/HPMC and PEG 200/glycerol. The optimum polymer-plasticiser combinations were then selected for further characterisation of tensile, hydration, adhesive properties by texture analysis and surface morphology by scanning electron microscopy. The results showed the potential of developing both fast and controlled release mucosal formulations by a combination of the two polymers.

History

Publication status

  • Published

Journal

International Journal of Biotechnology

ISSN

0963-6048

Publisher

Inderscience

Issue

3/4

Volume

11

Page range

169-181

Department affiliated with

  • Chemistry Publications

Full text available

  • No

Peer reviewed?

  • Yes

Legacy Posted Date

2016-01-29

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