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Continuous cocrystallisation of carbamazepine and trans-cinnamic acid via melt extrusion processing

journal contribution
posted on 2023-06-09, 00:11 authored by Hiren G Moradiya, Muhammad T Islam, Sheelagh Halsey, Mohammed Maniruzzaman, Babur Z Chowdhry, Martin J Snowden, D Douroumis
A solvent free process for the formation of carbamazepine (CBZ)–trans-cinnamic acid (TCA) cocrystals, in stoichiometric ratios, was developed using continuous hot melt extrusion processing. Physicochemical characterization of the CBZ–TCA extrudates included scanning electron microscopy (SEM), differential scanning calorimetry (DSC), X-ray powder diffraction (XRPD) and hot stage microscopy to evaluate the shape, morphology, purity and crystallinity of the freshly made cocrystals. The obtained cocrystals were of high quality compared to the prototype produced by a solvent crystallization technique. Furthermore, an in-line NIR probe was used to investigate the gradual formation of cocrystals during extrusion processing. The quality of the CBZ–TCA cocrystals was found to depend on the processing parameters such as temperature and the screw type. The extruded cocrystals showed faster dissolution rates compared to bulk CBZ and the prototype cocrystals.

History

Publication status

  • Published

Journal

CrystEngComm

ISSN

1466-8033

Publisher

Royal Society of Chemistry

Issue

17

Volume

16

Page range

3573

Department affiliated with

  • Chemistry Publications

Full text available

  • No

Peer reviewed?

  • Yes

Legacy Posted Date

2016-01-29

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