Meiotic DSB patterning: A multifaceted process

Cooper, Tim J, Garcia, Valerie and Neale, Matthew J (2016) Meiotic DSB patterning: A multifaceted process. Cell Cycle, 15 (1). pp. 13-21. ISSN 1538-4101

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Abstract

Meiosis is a specialized two-step cell division responsible for genome haploidization and the generation of genetic diversity during gametogenesis. An integral and distinctive feature of the meiotic program is the evolutionarily conserved initiation of homologous recombination (HR) by the developmentally programmed induction of DNA double-strand breaks (DSBs). The inherently dangerous but essential act of DSB formation is subject to multiple forms of stringent and self-corrective regulation that collectively ensure fruitful and appropriate levels of genetic exchange without risk to cellular survival. Within this article we focus upon an emerging element of this control—spatial regulation—detailing recent advances made in understanding how DSBs are evenly distributed across the genome, and present a unified view of the underlying patterning mechanisms employed.

Item Type: Article
Keywords: ATM, DSB formation, DSB hotspots, DSB interference, DSB competition, meiosis, recombination, Tel1
Schools and Departments: School of Life Sciences > Sussex Centre for Genome Damage and Stability
Subjects: Q Science > QR Microbiology > QR0001 General
Depositing User: Tim Cooper
Date Deposited: 18 Jan 2016 11:38
Last Modified: 06 Mar 2017 20:27
URI: http://sro.sussex.ac.uk/id/eprint/59268

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Biochemical reconstitution of DNA repair reactions on intact chromatinG0986EUROPEAN UNION311336