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Novel controlled release polymer-lipid formulations processed by hot melt extrusion

journal contribution
posted on 2023-06-09, 00:01 authored by Mohammed Maniruzzaman, Muhammad T Islam, Sheelagh Halsey, Devyani Amin, Dennis Douroumis
The aim of the study was to investigate the effect of novel polymer/lipid formulations on the dissolution rates of the water insoluble indomethacin (INM), co-processed by hot melt extrusion (HME). Formulations consisted of the hydrophilic hydroxypropyl methyl cellulose polymer (HPMCAS) and stearoyl macrogol-32 glycerides—Gelucire 50/13 (GLC) were processed with a twin screw extruder to produce solid dispersions. The extrudates characterized by X-ray powder diffraction (XRPD), differential scanning calorimetry (DSC) and hot stage microscopy (HSM) indicated the presence of amorphous INM within the polymer/lipid matrices. In-line monitoring via near-infrared (NIR) spectroscopy revealed significant peak shifts indicating possible interactions and H-bonding formation between the drug and the polymer/lipid carriers. Furthermore, in vitro dissolution studies showed a synergistic effect of the polymer/lipid carrier with 2-h lag time in acidic media followed by enhanced INM dissolution rates at pH?>?5.5.

History

Publication status

  • Published

Journal

AAPS PharmSciTech

ISSN

1530-9932

Publisher

Springer Verlag

Issue

1

Volume

17

Page range

191-199

Department affiliated with

  • Chemistry Publications

Full text available

  • No

Peer reviewed?

  • Yes

Legacy Posted Date

2016-01-29

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