The rate of adaptive evolution in animal mitochondria

James, Jennifer E, Piganeau, Gwenael and Eyre-Walker, Adam (2016) The rate of adaptive evolution in animal mitochondria. Molecular Ecology, 25 (1). pp. 67-78. ISSN 0962-1083

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Abstract

We have investigated whether there is adaptive evolution in mitochondrial DNA, using an extensive data set containing over 500 animal species from a wide range of taxonomic groups. We apply a variety of McDonald–Kreitman style methods to the data. We find that the evolution of mitochondrial DNA is dominated by slightly deleterious mutations, a finding which is supported by a number of previous studies. However, when we control for the presence of deleterious mutations using a new method, we find that mitochondria undergo a significant amount of adaptive evolution, with an estimated 26% (95% confidence intervals: 5.7–45%) of nonsynonymous substitutions fixed by adaptive evolution. We further find some weak evidence that the rate of adaptive evolution is correlated to synonymous diversity. We interpret this as evidence that at least some adaptive evolution is limited by the supply of mutations.

Item Type: Article
Schools and Departments: School of Life Sciences > Evolution, Behaviour and Environment
Depositing User: Adam Eyre-Walker
Date Deposited: 15 Jan 2016 10:33
Last Modified: 06 Mar 2017 15:29
URI: http://sro.sussex.ac.uk/id/eprint/59201

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