Mechanisms of regulation of mature miRNAs

Towler, Benjamin P, Jones, Christopher I and Newbury, Sarah F (2015) Mechanisms of regulation of mature miRNAs. Biochemical Society Transactions, 43 (6). pp. 1208-1214. ISSN 0300-5127

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Abstract

MicroRNAs (miRNAs) are short RNA molecules of around 22nt in length that play important roles in post-transcriptional control of gene expression. miRNAs normally function as negative regulators of mRNA expression by binding complementary sequences in the 3’ UTR of target mRNAs and causing translational repression and/or target degradation. Much research has been undertaken to enhance understanding of the biogenesis, function and targeting of miRNAs. However, until recently, the mechanisms underlying the regulation of the levels of mature miRNAs themselves have been largely overlooked. Although it has generally been assumed that miRNAs are stable molecules, recent evidence indicates that the stability of specific mature miRNAs can be regulated during key cellular and developmental processes in certain cell types. Here we discuss the current knowledge of the mechanisms by which mature miRNAs are regulated in the cell and the factors that contribute to the control of their stability.

Item Type: Article
Keywords: microRNAs, Drosophila Dis3, RNA stability
Schools and Departments: Brighton and Sussex Medical School > Brighton and Sussex Medical School
Subjects: Q Science > QH Natural history > QH0301 Biology > QH0426 Genetics
Q Science > QH Natural history > QH0301 Biology > QH0426 Genetics > QH0447 Genes. Alleles. Genome
Q Science > QL Zoology > QL0360 Invertebrates > QL0434 Arthropoda > QL0463 Insects > QL0531 Diptera (Flies)
Q Science > QP Physiology > QP0501 Animal biochemistry
Depositing User: Sarah Newbury
Date Deposited: 11 Jan 2016 15:52
Last Modified: 07 Mar 2017 10:54
URI: http://sro.sussex.ac.uk/id/eprint/59079

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Project NameSussex Project NumberFunderFunder Ref
Epigenetic regulation of gene expression by the exoribonuclease pacmanG0056BBSRC-BIOTECHNOLOGY & BIOLOGICAL SCIENCES RESEARCH COUNCILBB/I021345/1
Studentship-TowlerWC003-11BSMSWC003-11