Serum trace element concentrations in rheumatoid arthritis

Sahebari, Maryam, Ayati, Razie, Mirzaei, Hamed, Sahebkar, Amirhossein, Hejazi, Sepideh, Saghafi, Massoud, Saadati, Nayyereh, Ferns, Gordon A and Ghayour-Mobarhan, Majid (2016) Serum trace element concentrations in rheumatoid arthritis. Biological Trace Element Research, 171 (2). pp. 237-245. ISSN 0163-4984

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Abstract

Rheumatoid arthritis (RA) is a condition that is associated with oxidative stress. Serum trace elements and their related transport proteins, e.g., albumin and ceruloplasmin, play an important role in the antioxidant defense. Trace element status may therefore be involved in the pathogenesis of RA or be affected by the disease activity of this chronic inflammatory condition. The study participants were 110 patients with RA and 100 sex- and age-matched healthy volunteers. Serum concentrations of albumin, ceruloplasmin, selenium, zinc, copper, and zinc/copper ratio were measured in all subjects. The relationship between these parameters and disease activity score was also assessed. Lower concentrations of serum Alb, Zn, and Se were independently related to disease activity index. High concentrations of serum copper were associated with the presence of RA. Serum Cu concentrations were positively related to disease activity as assessed by the disease activity score. Low serum concentrations of Zn and Se, and high serum Cu concentrations may be associated with the presence of RA or be a consequence of this condition. Of the trace elements that were investigated in the present study, only serum Cu was positively correlated with disease activity.

Item Type: Article
Keywords: Albumin; Ceruloplasmin; Copper; DAS28ESR; Rheumatoid arthritis; Selenium; Trace elements; Zinc; Zinc to copper ratio
Schools and Departments: Brighton and Sussex Medical School > Division of Medical Education
Subjects: R Medicine
Depositing User: Elizabeth Morris
Date Deposited: 13 Jan 2016 11:08
Last Modified: 14 Jun 2016 11:54
URI: http://sro.sussex.ac.uk/id/eprint/58974
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