A triple helix model of medical innovation: supply, demand, and technological capabilities in terms of medical subject headings

Petersen, Alexander M, Rotolo, Daniele and Leydesdorff, Loet (2016) A triple helix model of medical innovation: supply, demand, and technological capabilities in terms of medical subject headings. Research Policy, 45 (3). pp. 666-681. ISSN 0048-7333

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Abstract

We develop a model of innovation that enables us to trace the interplay among three key dimensions of the innovation process: (i) demand of and (ii) supply for innovation, and (iii) technological capabilities available to generate innovation in the forms of products, processes, and services. Building on triple helix research, we use entropy statistics to elaborate an indicator of mutual information among these dimensions that can provide indication of reduction of uncertainty. To do so, we focus on the medical context, where uncertainty poses significant challenges to the governance of innovation. We use the Medical Subject Headings (MeSH) of MEDLINE/PubMed to identify publications classified within the categories “Diseases" (C), "Drugs and Chemicals" (D), "Analytic, Diagnostic, and Therapeutic Techniques and Equipment" (E) and use these as knowledge representations of demand, supply, and technological capabilities, respectively. Three case-studies of medical research areas are used as representative 'entry perspectives' of the medical innovation process. These are: (i) human papilloma virus, (ii) RNA interference, and (iii) magnetic resonance imaging. We find statistically significant periods of synergy among demand, supply, and technological capabilities (C-D-E) that point to three-dimensional interactions as a fundamental perspective for the understanding and governance of the uncertainty associated with medical innovation. Among the pairwise configurations in these contexts, the demand-technological capabilities (C-E) provided the strongest link, followed by the supply-demand (D-C) and the supply-technological capabilities (D-E) channels.

Item Type: Article
Keywords: innovation model; Triple helix; uncertainty; redundancy; synergy; mutual informa- tion; medical innovation; Medical Subject Headings; MEDLINE/PubMed
Schools and Departments: School of Business, Management and Economics > SPRU - Science Policy Research Unit
Subjects: H Social Sciences > H Social Sciences (General)
Depositing User: Daniele Rotolo
Date Deposited: 04 Jan 2016 15:30
Last Modified: 06 Mar 2017 23:19
URI: http://sro.sussex.ac.uk/id/eprint/58928

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Project NameSussex Project NumberFunderFunder Ref
NETGENESIS: The Genesis of Networks and Power - MC IOF Daniele RotoloG1280EUROPEAN UNIONPIOF-GA-2012-331107
Mapping the Dynamics of Emerging Technologies:G0499ESRC-ECONOMIC & SOCIAL RESEARCH COUNCILRES 360 25 0076