A 8-hydroxyquinoline-cyclodextrin conjugate as an efficient chelating agent for cobalt(II) and nickel(II) in neutral aqueous solution

Sgarlata, Carmelo, Oliveri, Valentina and Spencer, John (2015) A 8-hydroxyquinoline-cyclodextrin conjugate as an efficient chelating agent for cobalt(II) and nickel(II) in neutral aqueous solution. European Journal of Inorganic Chemistry, 2015 (36). pp. 5886-5891. ISSN 1434-1948

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Abstract

Chelating agents offer a versatile and effective means of removing toxic metal ions from the human body. Mounting evidence suggests that exposure to nickel and cobalt causes a number of adverse nasal/pulmonary health effects, skin hazards and allergies. In this context, the development of chelators that are able to bind nickel and cobalt with high stability constants is clearly crucial. Herein, the interaction of cobalt(II) and nickel(II) with a 8-hydroxyquinoline-cyclodextrin conjugate was investigated in aqueous solution at neutral pH. This family of chelator under study is potentially relevant in the treatment of diseases related to metal dyshomeostasis. Stability constants for the cobalt(II) and nickel(II) complexes were determined by competition experiments. The data indicate the formation of stable complexes, which were characterized by spectroscopic techniques. The collected information may provide new insights and suggest further strategies for the development of hydroxyquinoline derivatives for the control of cobalt and nickel toxicity.

Item Type: Article
Schools and Departments: School of Life Sciences > Chemistry
Subjects: Q Science > QD Chemistry > QD0146 Inorganic chemistry
Q Science > QD Chemistry > QD0241 Organic chemistry
Q Science > QD Chemistry > QD0241 Organic chemistry > QD0415 Biochemistry
Depositing User: John Spencer
Date Deposited: 14 Jan 2016 07:37
Last Modified: 08 Mar 2017 04:53
URI: http://sro.sussex.ac.uk/id/eprint/58856

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Project NameSussex Project NumberFunderFunder Ref
NPC-C: Adding a Chemistry Element to Niemann-Pick C ResearchG1484NPRFUnset
Travel Grant - Collaboration: Bio-inoragnic Chemistry, Manganese Chelation & CyclodextrinsG1401Royal Society of ChemistryUnset