Reactive oxygen-related diseases: therapeutic targets and emerging clinical indications

Casas, Ana I, Dao, V Thao-Vi, Daiber, Andreas, Maghzal, Ghassan J, Di Lisa, Fabio, Kaludercic, Nina, Leach, Sonia, Cuadrado, Antonio, Jaquet, Vincent, Seredenina, Tamara, Krause, Karl H, López, Manuela G, Stocker, Roland, Ghezzi, Pietro and Schmidt, Harald H H W (2015) Reactive oxygen-related diseases: therapeutic targets and emerging clinical indications. Antioxidants and Redox Signaling, 23 (14). pp. 1171-1185. ISSN 1523-0864

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Abstract

SIGNIFICANCE

Enhanced levels of reactive oxygen species (ROS) have been associated with different disease states. Most attempts to validate and exploit these associations by chronic antioxidant therapies have provided disappointing results. Hence, the clinical relevance of ROS is still largely unclear.

RECENT ADVANCES

We are now beginning to understand the reasons for these failures, which reside in the many important physiological roles of ROS in cell signaling. To exploit ROS therapeutically, it would be essential to define and treat the disease-relevant ROS at the right moment and leave physiological ROS formation intact. This breakthrough seems now within reach.

CRITICAL ISSUES

Rather than antioxidants, a new generation of protein targets for classical pharmacological agents includes ROS-forming or toxifying enzymes or proteins that are oxidatively damaged and can be functionally repaired.

FUTURE DIRECTIONS

Linking these target proteins in future to specific disease states and providing in each case proof of principle will be essential for translating the oxidative stress concept into the clinic. Antioxid. Redox Signal. 23, 1171-1185.

Item Type: Article
Schools and Departments: Brighton and Sussex Medical School > Clinical and Laboratory Investigation
Subjects: R Medicine
Depositing User: Patricia Butler
Date Deposited: 27 Nov 2015 15:45
Last Modified: 07 Mar 2017 04:49
URI: http://sro.sussex.ac.uk/id/eprint/58507

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