Cardiovascular and hepatic toxicity of cocaine: potential beneficial effects of modulators of oxidative stress

Graziani, Manuela, Antonilli, Letizia, Togna, Anna Rita, Grassi, Maria Caterina, Badiani, Aldo and Saso, Luciano (2016) Cardiovascular and hepatic toxicity of cocaine: potential beneficial effects of modulators of oxidative stress. Oxidative Medicine and Cellular Longevitiy, 2016. ISSN 1942-0900

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Abstract

Oxidative stress (OS) is thought to play an important role in the pharmacological and toxic effects of various drugs of abuse. Herein we review the literature on the mechanisms responsible for the cardiovascular and hepatic toxicity of cocaine with special focus on OS-related mechanisms. We also review the preclinical and clinical literature concerning the putative therapeutic effects of OS modulators (such as N-acetylcysteine, superoxide dismutase mimetics, nitroxides and nitrones, NADPH oxidase inhibitors, xanthine oxidase inhibitors, and mitochondriotropic antioxidants) for the treatment of cocaine toxicity. We conclude that available OS modulators do not appear to have clinical efficacy.

Item Type: Article
Schools and Departments: School of Psychology > Psychology
Subjects: B Philosophy. Psychology. Religion
Depositing User: Lene Hyltoft
Date Deposited: 19 Nov 2015 15:30
Last Modified: 08 Mar 2017 18:00
URI: http://sro.sussex.ac.uk/id/eprint/58051

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