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Time-delayed models of gene regulatory networks
journal contribution
posted on 2023-06-08, 22:58 authored by K Parmar, Konstantin BlyussKonstantin Blyuss, Yuliya KyrychkoYuliya Kyrychko, S J HoganWe discuss different mathematical models of gene regulatory networks as relevant to the onset and development of cancer. After discussion of alternativemodelling approaches, we use a paradigmatic two-gene network to focus on the role played by time delays in the dynamics of gene regulatory networks. We contrast the dynamics of the reduced model arising in the limit of fast mRNA dynamics with that of the full model. The review concludes with the discussion of some open problems.
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Publication status
- Published
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- Published version
Journal
Computational and Mathematical Methods in MedicineISSN
1748-6718Publisher
HindawiExternal DOI
Volume
2015Department affiliated with
- Mathematics Publications
Full text available
- Yes
Peer reviewed?
- Yes
Legacy Posted Date
2015-10-29First Open Access (FOA) Date
2015-10-29First Compliant Deposit (FCD) Date
2015-10-28Usage metrics
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