Substance-specific environmental influences on drug use and drug preference in animals and humans

Badiani, Aldo (2013) Substance-specific environmental influences on drug use and drug preference in animals and humans. Current Opinion in Neurobiology, 23 (4). pp. 588-596. ISSN 0959-4388

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Abstract

Epidemiological, clinical, and preclinical evidence indicate that the setting of drug use can exert a powerful modulatory influence on drug reward and that this influence is substance-specific. When heroin and cocaine co-abusers, for example, report on the circumstances of drug use, they indicate distinct settings for the two drugs: heroin being used preferentially at home and cocaine being used preferentially outside the home. Similar results were obtained in laboratory rats. These findings will be interpreted in the light of a novel model of drug reward, based on the emotional appraisal of central and peripheral drug effects as a function of environmental context. I argue here that drug addiction research has not paid sufficient attention to the substance-specific aspects of drug abuse and this may have contributed to the present dearth of effective treatments. Pharmacological and cognitive-behavioral therapy, for example, should be tailored so as to allow the addict to anticipate, and cope with, the risks associated, in a substance-specific manner, to the different settings of drug use.

Item Type: Article
Schools and Departments: School of Psychology > Psychology
Subjects: B Philosophy. Psychology. Religion
Depositing User: Lene Hyltoft
Date Deposited: 28 Oct 2015 12:30
Last Modified: 08 Mar 2017 06:05
URI: http://sro.sussex.ac.uk/id/eprint/57370

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