Cytokine and growth factor profiling in patients with the metabolic syndrome

Mirhafez, Seyed Reza, Pasdar, Alireza, Avan, Amir, Esmaily, Habibollah, Moezzi, Atefeh, Mohebati, Mohsen, Meshkat, Zahra, Mehrad-Majd, Hassan, Eslami, Saied, Rahimi, Hamid Reza, Ghazavi, Hamed, Ferns, Gordon A and Ghayour-Mobarhan, Majid (2015) Cytokine and growth factor profiling in patients with the metabolic syndrome. British Journal of Nutrition, 113 (12). pp. 1911-1919. ISSN 0007-1145

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Abstract

The metabolic syndrome (MetS) is associated with a pro-inflammatory milieu that may partially account for its association with an increased cardiovascular risk. We aimed to (1) evaluate the serum concentrations of twelve cytokines and growth factors (epidermal growth factor (EGF), interferon-γ (IFN-γ), IL-1α/-1β/-2/-4/-6/-8/-10, monocyte chemoattractant protein-1 (MCP-1), TNF-α and vascular endothelial growth factor (VEGF)) in 303 individuals with or without the MetS; and (2) explore their relationship with the presence of the MetS. Patients with the MetS had significantly higher serum concentrations of IFN-γ, EGF, IL-1α/-1β/-2/-4/-6/-8/-10, MCP-1 and TNF-α, whilst serum VEGF concentrations were markedly lower compared with the control group (e.g. 38-55 v. 82-18 pg/ml; P<0-05). Amongst these parameters, IFN-γ and IL-1α emerged as the most significant independent predictors of the MetS. In conclusion, our findings demonstrate that patients with the MetS had an altered blood cytokine and growth factor profile that may partially account for its adverse clinical outcomes. Further prospective studies in larger multi-centre settings are required to unravel the role and association of the emerging biomarkers with the MetS and their implication in therapeutic intervention. Copyright © The Authors 2015.

Item Type: Article
Additional Information: cited By 1
Schools and Departments: Brighton and Sussex Medical School > Division of Medical Education
Subjects: R Medicine
Depositing User: Sue Brown
Date Deposited: 26 Oct 2015 13:50
Last Modified: 26 Oct 2015 13:50
URI: http://sro.sussex.ac.uk/id/eprint/57312
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