Development of a medical imaging-based technology for cancer treatment

Lobstein-Adams, Chris (2015) Development of a medical imaging-based technology for cancer treatment. Doctoral thesis (PhD), University of Sussex.

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Abstract

The Electrical Impedance Mammography (EIM) device is an imaging system
developed at the University of Sussex for the detection of breast lesions in vivo using
quadrature detection of impedance.

The work describes a novel technique to integrate Ultrasound-guided Focused
Ultrasound Surgery (USgFUS) with the existing EIM system. The benefits that such a
system could provide include the possibility of non-invasive detection, diagnosis and
treatment of breast cancer all within a single device and involving no radiation.
Furthermore the timescales involved would allow the process to be considered an
outpatient procedure such that a patient can be diagnosed and treated on the same day
using the same device.

Various geometries of transducer were investigated for physical compatibility as
well as the ability to target the entire specified volume, based on the dimensions of the
existing system. Simulations were performed using a custom written code based on
Huygen’s principle, allowing minimum surface area and power requirements to be
determined and feasibility of designs to be evaluated.

The use of phase differences in the excitation signals applied to individual
elements was also investigated, thus the effect of steering the simulated focus could be
observed, an important factor to consider when attempting to incorporate a transducer
into a device with restricted dimensions.

Resulting simulated pressure fields were used to obtain acoustic intensity fields,
which could then be used as inputs in the Pennes Bio-Heat Transfer Equation (BHTE)
allowing temperature distributions to be observed.

Preliminary studies proved the feasibility of using the suggested transducer design
in conjunction with the existing EIM system. Pressure fields and heating patterns were
all within acceptable limits, confirming the ability of the device to effectively ablate
cancerous tissue. Additionally the capability to steer the resultant focal point was
validated, and a thermal dose model was implemented allowing different heating patterns
to be quantitatively compared.

Item Type: Thesis (Doctoral)
Schools and Departments: School of Engineering and Informatics > Engineering and Design
Subjects: R Medicine > RC Internal medicine > RC0071 Examination. Diagnosis Including radiography > RC0078 Radiography. General works > RC0078.7.E45 Electrical impedence tomography
R Medicine > RC Internal medicine > RC0254 Neoplasms. Tumors. Oncology Including cancer and carcinogens
Depositing User: Library Cataloguing
Date Deposited: 27 Oct 2015 12:48
Last Modified: 27 Oct 2015 12:48
URI: http://sro.sussex.ac.uk/id/eprint/56970

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