Central and effector memory CD4 and CD8 T-cell responses to tumor-associated antigens

Caserta, Stefano, Borger, Jessica Geraldine and Zamoyska, Rose (2012) Central and effector memory CD4 and CD8 T-cell responses to tumor-associated antigens. Critical Reviews in Immunology, 32 (2). pp. 97-126. ISSN 1040-8401

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Abstract

Harnessing T-cell responses to constrain tumor growth is a realistic treatment aspiration in tumor medicine, as many tumors express specific tumor associated antigens that are recognized by the adaptive immune system. CD8 T cells have direct cytolytic activity against tumor cells, and CD4 T cells mount a variety of responses that have important influences on tumor growth. We discuss how individual T-cell subsets contribute to antitumor responses and the goals and problems associated with generating and/or maintaining effective multifunctional T-cell responses to provide long-term protection against tumors.

Item Type: Article
Keywords: T cell biology; tumour immunology; immunotherapy
Schools and Departments: Brighton and Sussex Medical School > Clinical and Experimental Medicine
Brighton and Sussex Medical School > Global Health and Infection
Subjects: Q Science > QR Microbiology > QR0180 Immunology
R Medicine > RM Therapeutics. Pharmacology > RM0270 Immunotherapy. Serotherapy
Depositing User: Stefano Caserta
Date Deposited: 30 Sep 2015 06:48
Last Modified: 21 Sep 2017 13:52
URI: http://sro.sussex.ac.uk/id/eprint/56872
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