The role of PARPs in DNA strand break repair

Rulten, Stuart L, Dantzer, Francoise and Caldecott, Keith W (2015) The role of PARPs in DNA strand break repair. In: Curtin, Nicola J and Sharma, Ricky A (eds.) PARP Inhibitors for Cancer Therapy. Cancer Drug Discovery and Development, 83 . Humana Press, New York, pp. 47-78. ISBN 9783319141503

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Abstract

ADP-ribosylation is a post-translational modification in which a target protein becomes modified with monomeric, short chains, or long branching chains of ADP-ribose (ADPR). The process can be carried out by a number of ADP-ribosyltransferases and polymerases (ADP-RTs and PARPs) and the consequences of ribosylation are as diverse and heterogeneous as the products that are formed. In mammalian cells, only three PARPs bind to DNA, and their activity is stimulated by DNA ends. A number of roles for these three PARPs have been characterised, including several functions in DNA repair. The known repertoire of ADPR-binding proteins is vastly expanding, meaning that ribosylation increases the rate and complexity of ways in which DNA is repaired by a number of different ways.

Item Type: Book Section
Schools and Departments: School of Life Sciences > Sussex Centre for Genome Damage and Stability
Subjects: Q Science > QP Physiology
Depositing User: Stuart Rulten
Date Deposited: 18 Sep 2015 12:48
Last Modified: 05 Aug 2016 06:50
URI: http://sro.sussex.ac.uk/id/eprint/56823
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