Recognising facial onset sensory motor neuronopathy syndrome: insight from six new cases

Broad, R and Leigh, P N (2015) Recognising facial onset sensory motor neuronopathy syndrome: insight from six new cases. Practical Neurology, 15 (4). pp. 293-297. ISSN 1474-7758

Full text not available from this repository.

Abstract

Facial onset sensory and motor neuronopathy (FOSMN) was first described in 2006 as an apparently sporadic neurodegenerative disease. Thirty cases have been reported to date. We summarise six new cases, highlighting the key clinical aspects of FOSMN and how to differentiate it from motor neurone disease (amyotrophic lateral sclerosis). Typically, patients present with slowly evolving numbness of the face followed by bulbar and proximal (neck and arm) weakness. However, one of our patients presented with a motor syndrome and his abnormal blink reflex studies provided a useful diagnostic clue. This extends the spectrum of the syndrome and emphasises that FOSMN should be considered in the differential diagnosis of motor neurone disease. We discuss the pathophysiology, diagnosis, prognosis and management considerations of FOSMN.

Item Type: Article
Schools and Departments: Brighton and Sussex Medical School > Neuroscience
Subjects: R Medicine
R Medicine > RC Internal medicine > RC0321 Neurosciences. Biological psychiatry. Neuropsychiatry > RC0346 Neurology. Diseases of the nervous system Including speech disorders
Depositing User: Patricia Butler
Date Deposited: 16 Sep 2015 07:47
Last Modified: 25 Jul 2017 15:07
URI: http://sro.sussex.ac.uk/id/eprint/56775
📧 Request an update