File(s) not publicly available
Blood glucose responses to electrical stimulation of the hypothalamic feeding area
journal contribution
posted on 2023-06-08, 22:23 authored by David A Booth, Edward E Coons, Neal E MillerPassage of current for brief periods through electrodes in the lateral hypothalamus virtually always resulted in a distinctive biphasic hyperglycaemia in the case of electrodes capable of eliciting feeding at similar current intensities. The biphasic hyperglycaemic response was sometimes elicited by electrodes aimed at the feeding area but not capable of eliciting feeding. The response remained under pentobarbital anaesthesia. Electrodes in other regions of the hypothalamus gave monophasic hyperglycaemia or hypoglycaemia or no blood glucose change. The hyperglycaemic phases of the biphasic response were diminished by an adrenergic alpha-receptor blocking agent and by bilateral adrenal demedullation. The intermediate lowering of blood glucose concentration could be eliminated by injection of atropine or by sub-diaphragmatic bilateral vagotomy. It is therefore possible that the hypothalamic feeding system is directly connected to autonomic systems influencing endocrine regulation of glucose metabolism.
History
Publication status
- Published
Journal
Physiology and BehaviorISSN
0031-9384Publisher
ElsevierExternal DOI
Issue
6Volume
4Page range
991-1001Department affiliated with
- Psychology Publications
Full text available
- No
Peer reviewed?
- Yes
Legacy Posted Date
2015-09-03Usage metrics
Categories
No categories selectedKeywords
Licence
Exports
RefWorks
BibTeX
Ref. manager
Endnote
DataCite
NLM
DC