Feeding after a single insulin injection disrupted by puromycin but not actinomycin

Booth, David A, Love, Edith and Wechsler, Ann (1968) Feeding after a single insulin injection disrupted by puromycin but not actinomycin. Physiology and Behavior, 3 (3). pp. 455-460. ISSN 0031-9384

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Abstract

At doses which do not reduce food intake elicited by prior food deprivation, puromycin (12 mg/kg) and cycloheximide (0.5 mg/kg) reduce the food intake elicited from the rat by subcutaneous injection of solutions of bovine crystalline insulin (15–20 units/kg). Counteraction of hypoglycaemia by puromycin is not the cause of its blockade of insulin-induced feeding. The water intake evoked by insulin injection is, in contrast, not more sensitive to these drugs than is drinking after deprivation. Food intakes after insulin injection or after food deprivation are not differentially disrupted by actinomycin D (0.03–0.5 mg/kg) or 6-dimethylaminopurine (12 mg/kg). These results are consistent with the hypothesis that some metabolic adaptation to insulin-induced hypoglycaemia mediates the elicitation of feeding. They suggest that this effect of insulin depends on protein synthesis but is not mediated by ribonucleic acid synthesis dependent on deoxyribonucleic acid.

Item Type: Article
Schools and Departments: School of Psychology > Psychology
Subjects: B Philosophy. Psychology. Religion > BF Psychology > BF0180 Experimental psychology
Q Science > QD Chemistry > QD0241 Organic chemistry > QD0415 Biochemistry
Depositing User: prof. David Booth
Date Deposited: 03 Sep 2015 10:24
Last Modified: 03 Sep 2015 10:24
URI: http://sro.sussex.ac.uk/id/eprint/56519
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