Factors influencing flavour aversions conditioned with amphetamine in rats

D'Mello, G D, Stolerman, I P, Booth, D A and Pilcher, C W T (1977) Factors influencing flavour aversions conditioned with amphetamine in rats. Pharmacology Biochemistry and Behavior, 7 (3). pp. 185-190. ISSN 0091-3057

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Abstract

Rats would not drink distinctively flavoured solutions after their previous ingestion had been followed by injection of amphetamine (1 mg/kg). In the same rats, intake of flavoured solutions followed by saline injections was not suppressed. Providing the rats with cues as the location of flavoured solutions paired with amphetamine did not alter either the speed of development or the final severity of the aversion. Neither increasing the interval between presentation of the flavour and injection of amphetamine, nor decreasing baseline drinking levels, altered the final degree of aversion. The aversion became progressively weaker as the dose of amphetamine was reduced, but it was detectable at doses as low as 0.1 mg/kg. Further decreases in dose did not enhance intake of flavours paired with amphetamine, even when combined with reductions in baseline drinking brought about by reduced fluid deprivation and flavour palatability. The results are discussed in relation to the conditions in which amphetamine has been shown to exhibit either rewarding or aversive properties.

Item Type: Article
Schools and Departments: School of Psychology > Psychology
Subjects: B Philosophy. Psychology. Religion > BF Psychology > BF0180 Experimental psychology
Q Science > QP Physiology > QP0501 Animal biochemistry > QP0901 Experimental pharmacology
Depositing User: prof. David Booth
Date Deposited: 01 Sep 2015 14:49
Last Modified: 01 Sep 2015 14:49
URI: http://sro.sussex.ac.uk/id/eprint/56416
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