Comparative potencies of amphetamine, fenfluramine and related compounds in taste aversion experiments in rats

Booth, D A, Pilcher, C W T, D'Mello, G D and Stolerman, I P (1977) Comparative potencies of amphetamine, fenfluramine and related compounds in taste aversion experiments in rats. British Journal of Pharmacology, 61 (4). pp. 669-677. ISSN 0007-1188

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Abstract

1 Rats failed to drink a flavoured solution when its consumption had been followed by injection of amphetamine (conditioned taste aversion).

2 There was very little difference between the potencies of (+)- and (-)-amphetamine.

3 p-Chloromethamphetamine was a more potent aversive agent than methamphetamine.

4 Strong taste aversions were also conditioned with other congeners of amphetamine. The rank order of potency was: fenfluramine > chlorphentermine >p-hydroxyamphetamine.

5 Cocaine induced only moderate taste aversions, even at high doses.

6 Aversive potency did not appear to be correlated with known neurochemical actions of the drugs or with behavioural stimulation, but appeared to be a central action which may have been linked to anorexigenic potency or time course of action.

Item Type: Article
Schools and Departments: School of Psychology > Psychology
Subjects: B Philosophy. Psychology. Religion > BF Psychology > BF0180 Experimental psychology
Q Science > QP Physiology > QP0501 Animal biochemistry > QP0901 Experimental pharmacology
Depositing User: prof. David Booth
Date Deposited: 01 Sep 2015 14:45
Last Modified: 01 Sep 2015 14:45
URI: http://sro.sussex.ac.uk/id/eprint/56415
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