Ontogeny and insulin-dependence of the satiation which follows carbohydrate absorption in the rat

Booth, David A and Jarman, Simon P (1975) Ontogeny and insulin-dependence of the satiation which follows carbohydrate absorption in the rat. Behavioral Biology, 15 (2). pp. 159-172. ISSN 0091-6773

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Abstract

In adult rats, the first meal on restoring access to food following the complete absorption of an intragastric carbohydrate load is smaller than the meal following a nonnutritive load. The weanling rat does not show this postabsorptively induced satiation. The effect does not appear until above a body weight of about 200 g. Subcutaneous injection of a moderate dose of insulin (0.2 units/kg) at the time of glucose intubation results in postabsorptive satiety appearing in the immature rat. The inhibitor of insulin secretion, D-mannoheptulose, injected shortly before glucose intubation, considerably reduces the satiety effect in the 300 g rat. It is suggested that an abundant secretion of insulin during absorption is necessary to establish the parenteral satiety signal operative under these conditions.

Item Type: Article
Schools and Departments: School of Psychology > Psychology
Subjects: B Philosophy. Psychology. Religion > BF Psychology > BF0180 Experimental psychology
Q Science > QD Chemistry > QD0241 Organic chemistry > QD0415 Biochemistry
Depositing User: prof. David Booth
Date Deposited: 01 Sep 2015 13:40
Last Modified: 01 Sep 2015 13:40
URI: http://sro.sussex.ac.uk/id/eprint/56402
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