Low dose response for 2 deoxy D glucose induced feeding and the involvement of peripheral factors

Jones, R G and Booth, D A (1975) Low dose response for 2 deoxy D glucose induced feeding and the involvement of peripheral factors. Physiology and Behavior, 15 (1). pp. 85-90. ISSN 0031-9384

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Abstract

Latencies to feed and meal sizes were observed in recently satiated rats injected intraperitoneally with an isotonic solution of 2-deoxyglucose, using 3-O-methyl glucose for the control injection. The feeding response latency shortened monotonically with dose from about 0.3 mmole/kg (50 mg/kg) to 0.5–0.6 mmole/kg, with an extended plateau up to debilitating doses. At modest doses, the latency to feed was shorter in adrenal demedullated rats than in intact rats, suggesting that the hyperglycemic response to 2DG partially inhibits the feeding response. Food-deprived rats took larger meals following 2DG injection, if there had been recent rapid intestinal absorption of glucose. It is suggested that a major action of 2DG is to block the satiating consequences of the process of absorption, possibly at hepatic receptors.

Item Type: Article
Schools and Departments: School of Psychology > Psychology
Subjects: Q Science > QD Chemistry > QD0241 Organic chemistry > QD0415 Biochemistry
Q Science > QP Physiology
R Medicine > RC Internal medicine > RC0321 Neurosciences. Biological psychiatry. Neuropsychiatry
Depositing User: prof. David Booth
Date Deposited: 01 Sep 2015 13:36
Last Modified: 01 Sep 2015 13:36
URI: http://sro.sussex.ac.uk/id/eprint/56401
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