Tolerance in the depression of intake when amphetamine is added to the rat's food

Panksepp, Jaak and Booth, D A (1973) Tolerance in the depression of intake when amphetamine is added to the rat's food. Psychopharmacologia, 29 (1). pp. 45-54. ISSN 0033-3158

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Abstract

The depression of intake initially seen when a rat is placed on an amphetamine adulterated diet disappears over a week at the dose level of 0.2 mg amphetamine per gram of chow. The decreased effectiveness of amphetamine is attributable primarily to accruing deprivation rather than to either behavioral or pharmacological tolerance. Ventromedial hypothalamic lesions attenuate the tolerance, whereas lateral hypothalamic lesions decrease the basic anorexigenic effect of amphetamine.

Item Type: Article
Schools and Departments: School of Psychology > Psychology
Subjects: B Philosophy. Psychology. Religion > BF Psychology > BF0180 Experimental psychology
Q Science > QP Physiology > QP0501 Animal biochemistry > QP0901 Experimental pharmacology
R Medicine > RC Internal medicine > RC0321 Neurosciences. Biological psychiatry. Neuropsychiatry
Depositing User: prof. David Booth
Date Deposited: 01 Sep 2015 12:39
Last Modified: 01 Sep 2015 12:39
URI: http://sro.sussex.ac.uk/id/eprint/56389
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