Reflection_impulsivity_in_binge_drinking_behavioural_and_volumetric_correlates_Impulsivity_in_binge_drinking.pdf (529.9 kB)
Reflection impulsivity in binge drinking: behavioural and volumetric correlates
journal contribution
posted on 2023-06-08, 22:06 authored by Paula Banca, Iris Lange, Yulia Worbe, Nicholas Howell, Michael Irvine, Neil Harrison, Michael Moutoussis, Voon ValerieThe degree to which an individual accumulates evidence prior to making a decision, also known as reflection impulsivity, can be affected in psychiatric disorders. Here, we study decisional impulsivity in binge drinkers, a group at elevated risk for developing alcohol use disorders, comparing two tasks assessing reflection impulsivity and a delay discounting task, hypothesizing impairments in both subtypes of impulsivity. We also assess volumetric correlates of reflection impulsivity focusing on regions previously implicated in functional magnetic resonance imaging studies. Sixty binge drinkers and healthy volunteers were tested using two different information-gathering paradigms: the beads task and the Information Sampling Task (IST). The beads task was analysed using a behavioural approach and a Bayesian model of decision making. Delay discounting was assessed using the Monetary Choice Questionnaire. Regression analyses of primary outcomes were conducted with voxel-based morphometry analyses. Binge drinkers sought less evidence prior to decision in the beads task compared with healthy volunteers in both the behavioural and computational modelling analysis. There were no group differences in the IST or delay discounting task. Greater impulsivity as indexed by lower evidence accumulation in the beads task was associated with smaller dorsolateral prefrontal cortex and inferior parietal volumes. In contrast, greater impulsivity as indexed by lower evidence accumulation in the IST was associated with greater dorsal cingulate and precuneus volumes. Binge drinking is characterized by impaired reflection impulsivity suggesting a deficit in deciding on the basis of future outcomes that are more difficult to represent. These findings emphasize the role of possible therapeutic interventions targeting decisionmaking deficits.
History
Publication status
- Published
File Version
- Published version
Journal
Addiction BiologyISSN
1355-6215Publisher
WileyExternal DOI
Issue
2Volume
21Page range
504-515Department affiliated with
- BSMS Neuroscience Publications
Full text available
- Yes
Peer reviewed?
- Yes
Legacy Posted Date
2015-08-13First Open Access (FOA) Date
2015-08-13First Compliant Deposit (FCD) Date
2015-08-13Usage metrics
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