Reflection impulsivity in binge drinking: behavioural and volumetric correlates

Banca, Paula, Lange, Iris, Worbe, Yulia, Howell, Nicholas, Irvine, Michael, Harrison, Neil A, Moutoussis, Michael and Valerie, Voon (2016) Reflection impulsivity in binge drinking: behavioural and volumetric correlates. Addiction Biology, 21 (2). pp. 504-515. ISSN 1355-6215

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Abstract

The degree to which an individual accumulates evidence prior to making a decision, also known as reflection impulsivity, can be affected in psychiatric disorders. Here, we study decisional impulsivity in binge drinkers, a group at elevated risk for developing alcohol use disorders, comparing two tasks assessing reflection impulsivity and a delay discounting task, hypothesizing impairments in both subtypes of impulsivity. We also assess volumetric correlates of reflection impulsivity focusing on regions previously implicated in functional magnetic resonance imaging studies.

Sixty binge drinkers and healthy volunteers were tested using two different information-gathering paradigms: the
beads task and the Information Sampling Task (IST). The beads task was analysed using a behavioural approach and
a Bayesian model of decision making. Delay discounting was assessed using the Monetary Choice Questionnaire.
Regression analyses of primary outcomes were conducted with voxel-based morphometry analyses. Binge drinkers
sought less evidence prior to decision in the beads task compared with healthy volunteers in both the behavioural
and computational modelling analysis. There were no group differences in the IST or delay discounting task. Greater
impulsivity as indexed by lower evidence accumulation in the beads task was associated with smaller dorsolateral
prefrontal cortex and inferior parietal volumes. In contrast, greater impulsivity as indexed by lower evidence accumulation in the IST was associated with greater dorsal cingulate and precuneus volumes. Binge drinking is characterized by impaired reflection impulsivity suggesting a deficit in deciding on the basis of future outcomes that are more difficult to represent. These findings emphasize the role of possible therapeutic interventions targeting decisionmaking deficits.

Item Type: Article
Schools and Departments: Brighton and Sussex Medical School > Neuroscience
Subjects: R Medicine > RC Internal medicine > RC0321 Neurosciences. Biological psychiatry. Neuropsychiatry
Depositing User: Jonathan Williams
Date Deposited: 13 Aug 2015 13:12
Last Modified: 18 Jul 2017 22:52
URI: http://sro.sussex.ac.uk/id/eprint/56099

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