Jumping_the_Gun_Mapping_Neural_Correlates_of_Waiting_Impulsivity_and_Relevance_Across_Alcohol_Misuse.pdf (1.14 MB)
Jumping the gun: mapping neural correlates of waiting impulsivity and relevance across alcohol misuse
journal contribution
posted on 2023-06-08, 22:06 authored by Neil Harrison, Prantik Kundu, Kwangyeol Baek, Michael A Irvine, Daisy J Mechelmans, Jonathan Wood, Trevor W Robbins, Edward T Bullmore, Valerie Voon, Laurel S MorrisBACKGROUND: Why do we jump the gun or speak out of turn? Waiting impulsivity has a preclinical basis as a predictor for the development of addiction. Here, we mapped the intrinsic neural correlates of waiting and dissociated it from stopping, both fundamental mechanisms of behavioral control. METHODS: We used a recently developed translational task to assess premature responding and assess response inhibition using the stop signal task. We mapped the neural correlates in 55 healthy volunteers using a novel multiecho resting-state functional magnetic resonance imaging sequence and analysis, which robustly boosts signal-tonoise ratio. We further assessed 32 young binge drinkers and 36 abstinent subjects with alcohol use disorders. RESULTS: Connectivity of limbic and motor cortical and striatal nodes mapped onto a mesial-lateral axis of the subthalamic nucleus. Waiting impulsivity was associated with lower connectivity of the subthalamic nucleus with ventral striatum and subgenual cingulate, regions similarly implicated in rodent lesion studies. This network was dissociable from fast reactive stopping involving hyperdirect connections of the pre-supplementary area and subthalamic nucleus. We further showed that binge drinkers, like those with alcohol use disorders, had elevated premature responding and emphasized the relevance of this subthalamic network across alcohol misuse. Using machine learning techniques we showed that subthalamic connectivity differentiates binge drinkers and individuals with alcohol use disorders from healthy volunteers. CONCLUSIONS: We highlight the translational and clinical relevance of dissociable functional systems of cortical, striatal, and hyperdirect connections with the subthalamic nucleus in modulating waiting and stopping and their importance across dimensions of alcohol misuse.
History
Publication status
- Published
File Version
- Accepted version
Journal
Biological PsychiatryISSN
0006-3223Publisher
ElsevierExternal DOI
Issue
6Volume
79Page range
499-507Department affiliated with
- BSMS Neuroscience Publications
Full text available
- Yes
Peer reviewed?
- Yes
Legacy Posted Date
2015-08-13First Open Access (FOA) Date
2015-08-13First Compliant Deposit (FCD) Date
2015-08-13Usage metrics
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