DNA Binders: 1. Evaluation of DNA-Interactive Ability, Design, and Synthesis of Novel Intercalating Agents

Sechi, Mario, Derudas, Marco, Dallocchio, Roberto, Dessì, Alessandro, Cosseddu, Alessia and Paglietti, Giuseppe (2009) DNA Binders: 1. Evaluation of DNA-Interactive Ability, Design, and Synthesis of Novel Intercalating Agents. Letters in Drug Design and Discovery, 6 (1). pp. 56-62. ISSN 1570-1808

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Abstract

Previously, we designed and synthesized the 2,3,6,7-tetrahydro-1H-pyrrolo[1,2-a]indole-1,8(5H)-dione as a versatile structural platform to be functionalized to obtain potential DNA-interactive agents by intercalation and/or reversible enzyme inhibition. Herein, we report an alternative synthetic route for the preparation of this heterocyclic template as well as the synthesis of an its “two-armed” derivative. Also, a computational docking study to investigate the possible DNA-binding mode of well-known binders and title compound was performed.

Item Type: Article
Schools and Departments: School of Life Sciences > Chemistry
Depositing User: Marco Derudas
Date Deposited: 28 Jul 2015 10:56
Last Modified: 28 Jul 2015 10:56
URI: http://sro.sussex.ac.uk/id/eprint/55787
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