Understanding the roles of activation threshold and infections in the dynamics of autoimmune disease

Blyuss, K B and Nicholson, L B (2015) Understanding the roles of activation threshold and infections in the dynamics of autoimmune disease. Journal of Theoretical Biology, 375. pp. 13-20. ISSN 0022-5193

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Abstract

Onset and development of autoimmunity have been attributed to a number of factors, including genetic predisposition, age and different environmental factors. In this paper we discuss mathematical models of autoimmunity with an emphasis on two particular aspects of immune dynamics: breakdown of immune tolerance in response to an infection with a pathogen, and interactions between T cells with different activation thresholds. We illustrate how the explicit account of T cells with different activation thresholds provides a viable model of immune dynamics able to reproduce several types of immune behaviour, including normal clearance of infection, emergence of a chronic state, and development of a recurrent infection with autoimmunity. We discuss a number of open research problems that can be addressed within the same modelling framework.

Item Type: Article
Schools and Departments: School of Mathematical and Physical Sciences > Mathematics
Subjects: T Technology > T Technology (General) > T0055.4 Industrial engineering. Management engineering > T0057 Applied mathematics. Quantitative methods
Depositing User: Konstantin Blyuss
Date Deposited: 24 Jul 2015 13:12
Last Modified: 08 Mar 2017 06:45
URI: http://sro.sussex.ac.uk/id/eprint/55743

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