Psychomotor retardation and vulnerability to interferon alpha induced major depressive disorder: prospective study of a chronic hepatitis C cohort

Whale, Richard, Fialho, Renata Sofia, Rolt, Michael, Eccles, Jessica, Pereira, Marco, Keller, Majella, File, Alexandra, Haq, Inam and Tibble, Jeremy (2015) Psychomotor retardation and vulnerability to interferon alpha induced major depressive disorder: prospective study of a chronic hepatitis C cohort. Journal of Psychosomatic Research, 79 (6). pp. 640-645. ISSN 0022-3999

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Abstract

BACKGROUND:

Major depressive disorder (MDD) is a common consequence of interferon alpha (IFNα) treatment and important supporting evidence of a role of inflammation in the aetiology of depression.

OBJECTIVE:

This study aimed to expand the knowledge of baseline clinical vulnerability characteristics to IFNα induced MDD, particularly exploring sub-threshold depressive symptoms.

METHODS:

A prospective cohort of chronic HCV patients undergoing treatment with pegylated-IFNα and ribavirin was studied. MDD was assessed using the Structured Clinical Interview for DSM-IV (SCID-I). Depressive symptoms and severity were assessed at baseline and monthly with the Hamilton Depression Rating Scale (HAMD). Subjects with MDD or taking antidepressant treatment at baseline were excluded.

RESULTS:

278 patients were assessed for this cohort with a final study sample of 190. 94.2% had contracted HCV through intravenous drug use. During six months IFNα treatment, 53.2% of patients transitioned to DSM-IV threshold MDD. In the multivariate logistic analysis, independent factors significantly associated with development of MDD were younger age (OR 0.96, 95% CI 0.93-1.00, p=0.028), past history of MDD (OR 3.82, 95% CI 1.63-8.92, p=0.002), baseline HAMD items psychomotor retardation (OR 15.21, 95% CI 1.33-173.41, p=0.032) and somatic symptoms (general) (OR 2.96, 95% CI 1.44-6.08, p=0.003), and HCV genotype 2 (OR 2.27, 95% CI 1.07-4.78, p=0.032).

CONCLUSIONS:

During IFNα treatment, the rate of transition to MDD was high in this cohort. Psychomotor retardation and somatic symptoms may represent a greater inflamed state pre-treatment. This iatrogenic model of MDD may offer important insights into wider depression aetiology.

Item Type: Article
Keywords: Depressive disorder; Inflammation; Hepatitis C; Interferon-alpha; Prospective studies
Schools and Departments: Brighton and Sussex Medical School > Division of Medical Education
Brighton and Sussex Medical School > Neuroscience
Subjects: Q Science > QZ Psychology
R Medicine
R Medicine > RC Internal medicine > RC0321 Neurosciences. Biological psychiatry. Neuropsychiatry > RC0438 Psychiatry
Depositing User: Elizabeth Morris
Date Deposited: 23 Jul 2015 15:09
Last Modified: 25 Jul 2017 14:13
URI: http://sro.sussex.ac.uk/id/eprint/55709
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