Design and synthesis of novel polycycles based on the 3H-pyrrolo/6,7-dihydropyrido[1,2-a]indole scaffold as templates for pharmaceutical development

Derudas, Marco, Pala, Nicolino, Sanna, Vanna, Dallocchio, Roberto, Dessì, Alessandro, Roggio, Anna Maria and Sechi, Mario (2011) Design and synthesis of novel polycycles based on the 3H-pyrrolo/6,7-dihydropyrido[1,2-a]indole scaffold as templates for pharmaceutical development. Journal of Heterocyclic Chemistry, 48 (5). pp. 1161-1168. ISSN 0022-152X

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Abstract

In the course of our work aimed at developing novel heterocycles of pharmaceutical interest, we designed and synthesized several polycyclic templates as potential substrates to be used in drug design. We obtained a set of condensed ring systems as versatile structural platforms to generate potential DNA-interactive agents and/or reversible inhibitors of enzymes such as topoisomerases, poly(ADP-ribose) polymerase-1 (PARP-1), telomerase, and, in particular, cyclin dependent kinases. Herein, we report the design, synthesis, structural investigation, and preliminary DNA-binding affinity of these heteroaromatic systems. J. Heterocyclic Chem., (2011).

Item Type: Article
Schools and Departments: School of Life Sciences > Chemistry
Depositing User: Marco Derudas
Date Deposited: 22 Jul 2015 15:11
Last Modified: 22 Jul 2015 15:11
URI: http://sro.sussex.ac.uk/id/eprint/55685
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