Investigation of furo[2,3-h]- and pyridazino[3,4-f]cinnolin-3-ol scaffolds as substrates for the development of novel HIV-1 integrase inhibitors

Gomaa, Mohamed F Y, Pala, Nicolino, Derudas, Marco, Hasanen, Jehan Abd-Elrazik, El-Tamany, El-Sayed H, Casule, Paola, Mariani, Alberto and Sechi, Mario (2011) Investigation of furo[2,3-h]- and pyridazino[3,4-f]cinnolin-3-ol scaffolds as substrates for the development of novel HIV-1 integrase inhibitors. Arkivoc, 2011 (9). pp. 1-14. ISSN 1551-7012

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Abstract

With the aim to develop novel HIV-1 integrase inhibitors, we obtained a set of condensed ring systems based on the furo[2,3-h]cinnolin-3(2H)-one and pyridazino[3,4-f]cinnolin-3-ol scaffolds bearing a potential chelating pharmacophore, which can be involved in the inhibition mechanism of the enzyme. Herein, we report the design, synthesis, structural investigation and preliminary biological results of these heteroaromatic systems.

Item Type: Article
Schools and Departments: School of Life Sciences > Chemistry
Depositing User: Marco Derudas
Date Deposited: 23 Jul 2015 06:14
Last Modified: 22 Mar 2017 07:14
URI: http://sro.sussex.ac.uk/id/eprint/55679

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