AMPA receptor-positive allosteric modulators for the treatment of schizophrenia: an overview of recent patent applications

Ward, Simon E, Pennicott, Lewis E and Beswick, Paul (2015) AMPA receptor-positive allosteric modulators for the treatment of schizophrenia: an overview of recent patent applications. Future Medicinal Chemistry, 7 (4). pp. 473-491. ISSN 1756-8919

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Abstract

The role of glutamate and its receptors in central nervous system biology and disease has long been of interest to scientists involved in both fundamental research and drug discovery, however the complex pharmacology and lack of highly selective compounds has severely hampered drug discovery efforts in this area. Recent advances in the identification and profiling of positive allosteric modulators of the AMPA receptor offer a potential way forward and the hope of a new treatment for schizophrenia. This article will review recent patent applications published in this area.

Item Type: Article
Schools and Departments: School of Life Sciences > Chemistry
Subjects: R Medicine > RS Pharmacy and materia medica > RS0153 Materia medica > RS0400 Pharmaceutical chemistry
Depositing User: Lewis Pennicott
Date Deposited: 21 Jul 2015 06:59
Last Modified: 08 Mar 2017 06:42
URI: http://sro.sussex.ac.uk/id/eprint/55654

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