The contribution of gene-environment interaction to psychopathology

Thapar, Anita, Harold, Gordon, Rice, Frances, Langley, Kate and O'Donovan, Michael (2007) The contribution of gene-environment interaction to psychopathology. Development and Psychopathology, 19 (4). pp. 989-1004. ISSN 0954-5794

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Abstract

The study of gene-environment interaction (G × E) constitutes an area of significant social and clinical significance. Different types of research study designs are being used to investigate the contribution of G × E to psychopathology, although the term G × E has also been used and interpreted in different ways. Despite mixed evidence that G × E contributes to psychopathology, some promising and consistent findings are emerging. Evidence is reviewed in relation to depression, antisocial behavior, schizophrenia, and attention-deficit/hyperactivity disorder. Although findings from various research designs have different meaning, interestingly much of the evidence with regard to the contribution of G × E that has arisen from twin and adoption studies has been for antisocial behavior and depression. It is for these same forms of psychopathology that molecular genetic evidence of G × E has also been most convincing. Finally, current and anticipated methodological challenges and implications for future research in this area are considered.

Item Type: Article
Schools and Departments: School of Psychology > Psychology
Subjects: B Philosophy. Psychology. Religion > BF Psychology
Depositing User: Carmel Stevenson
Date Deposited: 11 Aug 2015 15:01
Last Modified: 11 Aug 2015 15:01
URI: http://sro.sussex.ac.uk/id/eprint/55521
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