The role of ras gene in the development of haemic neoplasia in Mytilus trossulus

Ciocan, C. M., Moore, J. D. and Rotchell, J. M. (2006) The role of ras gene in the development of haemic neoplasia in Mytilus trossulus. Marine Environmental Research, 62 Sup. S147-50. ISSN 0141-1136

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Abstract

Disseminated neoplasia has been reported in mussels (Mytilus spp) from numerous locations worldwide. This condition is progressive and fatal and the aetiology is unknown. In vertebrates, oncogenes such as ras, and tumour suppressor genes such as p53, play important roles in carcinogenesis. We have cloned a Mytilus trossulus homologue of the vertebrate ras gene, which shows conserved sequence in regions of functional importance. Neoplastic hemolymph samples derived from M. trossulus have been investigated for the presence of ras gene mutations and changes in expression.

Item Type: Article
Schools and Departments: School of Life Sciences > Biology and Environmental Science
Subjects: Q Science > QD Chemistry
Q Science > QH Natural history > QH0301 Biology
Depositing User: Corina Ciocan
Date Deposited: 23 Nov 2006
Last Modified: 10 Mar 2017 18:13
URI: http://sro.sussex.ac.uk/id/eprint/549
Google Scholar:9 Citations

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