Widespread alterations in functional brain network architecture in amnestic mild cognitive impairment

Minati, Ludovico, Chan, Dennis, Mastropasqua, Chiara, Serra, Laura, Spanò, Barbara, Marra, Camillo, Caltagirone, Carlo, Cercignani, Mara and Bozzali, Marco (2014) Widespread alterations in functional brain network architecture in amnestic mild cognitive impairment. Journal of Alzheimer's Disease, 40 (1). pp. 213-220. ISSN 1875-8908

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Abstract

We investigated changes in functional network architecture in amnestic mild cognitive impairment using graph-based analysis of task-free functional magnetic resonance imaging and fine cortical parcellation. Widespread disconnection was observed primarily in cortical hubs known to manifest early Alzheimer's disease pathology, namely precuneus, parietal lobules, supramarginal and angular gyri, and cuneus, with additional involvement of subcortical regions, sensorimotor cortex and insula. The connectivity changes determined using graph-based analysis significantly exceed those detected using independent component analysis both in amplitude and topographical extent, and are largely decoupled from the presence of overt atrophy. This superior ability of graph-based analysis to detect disease-related disconnection highlights its potential use in the determination of biomarkers of early dementia. Graph-based analysis source code is provided as supplementary material.

Item Type: Article
Schools and Departments: Brighton and Sussex Medical School > Neuroscience
Subjects: R Medicine > RC Internal medicine > RC0321 Neurosciences. Biological psychiatry. Neuropsychiatry > RC0346 Neurology. Diseases of the nervous system Including speech disorders
Depositing User: Patricia Butler
Date Deposited: 27 Nov 2015 09:18
Last Modified: 24 Jul 2017 17:32
URI: http://sro.sussex.ac.uk/id/eprint/54573
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