Effects of Aβ exposure on long-term associative memory and its neuronal mechanisms in a defined neuronal network

Ford, Lenzie, Crossley, Michael, Williams, Thomas, Thorpe, Julian R, Serpell, Louise C and Kemenes, György (2015) Effects of Aβ exposure on long-term associative memory and its neuronal mechanisms in a defined neuronal network. Scientific Reports, 5. p. 10614. ISSN 2045-2322

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Abstract

Amyloid beta (Aβ) induced neuronal death has been linked to memory loss, perhaps the most devastating symptom of Alzheimer’s disease (AD). Although Aβ-induced impairment of synaptic or intrinsic plasticity is known to occur before any cell death, the links between these neurophysiological changes and the loss of specific types of behavioral memory are not fully understood. Here we used a behaviorally and physiologically tractable animal model to investigate Aβ-induced memory loss and electrophysiological changes in the absence of neuronal death in a defined network underlying associative memory. We found similar behavioral but different neurophysiological effects for Aβ 25-35 and Aβ 1-42 in the feeding circuitry of the snail Lymnaea stagnalis. Importantly, we also established that both the behavioral and neuronal effects were dependent upon the animals having been classically conditioned prior to treatment, since Aβ application before training caused neither memory impairment nor underlying neuronal changes over a comparable period of time following treatment.

Item Type: Article
Keywords: Long-term memory, Alzheimer's disease
Schools and Departments: School of Life Sciences > Neuroscience
Depositing User: Helen Webb - Library
Date Deposited: 01 Jun 2015 11:47
Last Modified: 07 Mar 2017 08:16
URI: http://sro.sussex.ac.uk/id/eprint/54225

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Project NameSussex Project NumberFunderFunder Ref
Abeta-mediated toxicity in Alzheimer's disease: delineating mechanisms of internalisation, cell-cell transmission and synaptic dysfunction.G1106MRC-MEDICAL RESEARCH COUNCILMR/K022105/1
Decision Making in Neural Networks: Influence of LearningG0189BBSRC-BIOTECHNOLOGY & BIOLOGICAL SCIENCES RESEARCH COUNCILBB/H009906/1