Genetic and epigenetic studies of amyotrophic lateral sclerosis

Al-Chalabi, Ammar, Kwak, Shin, Mehler, Mark, Rouleau, Guy, Siddique, Teepu, Strong, Michael and Leigh, Peter Nigel (2013) Genetic and epigenetic studies of amyotrophic lateral sclerosis. Amyotrophic lateral sclerosis & frontotemporal degeneration, 14 (S1). pp. 44-52. ISSN 2167-9223

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Abstract

The identification of genetic and epigenetic factors that are associated with an increased risk of developing amyotrophic lateral sclerosis (ALS), or that modify the age of onset or rate of progression, requires a multimodal research strategy, facilitated through international collaboration. The discovery of several ALS genes strongly linked to RNA biology, the proteasome pathway, and axonal transport suggest they have an important role in pathogenesis, but the immense complexity of these processes is also apparent. The increasing rate of genetic discoveries brings the hope of designing more targeted and efficacious therapies.

Item Type: Article
Keywords: ALS, genetic, epigenetic, familial ALS, modifier genes
Schools and Departments: Brighton and Sussex Medical School > Neuroscience
Subjects: R Medicine
R Medicine > RC Internal medicine > RC0321 Neurosciences. Biological psychiatry. Neuropsychiatry > RC0346 Neurology. Diseases of the nervous system Including speech disorders
Depositing User: Patricia Butler
Date Deposited: 01 Jun 2015 11:46
Last Modified: 27 Jul 2017 18:23
URI: http://sro.sussex.ac.uk/id/eprint/54184
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