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Aryloxypyrazines as highly selective antagonists of Oxytocin

journal contribution
posted on 2023-06-08, 20:55 authored by Alan Brown, Dave Ellis, David Pearce, Michael Ralph, Nunzio Sciammetta
A series of aryloxypyrazines were designed based on structural overlap with previously reported arylpyrazine Oxytocin antagonists. Similarly high levels of Oxytocin antagonism were achievable in this new series. In addition, significant improvements in selectivity over the related vasopressin V1A receptor were also possible.

History

Publication status

  • Published

Journal

Bioorganic and Medicinal Chemistry Letters

ISSN

0960-894X

Publisher

Elsevier

Issue

10

Volume

19

Page range

2634-2636

Department affiliated with

  • Chemistry Publications

Full text available

  • No

Peer reviewed?

  • Yes

Legacy Posted Date

2015-06-01

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