Lead diversification 2: application to P38, gMTP and lead compounds

Masood, M Abid, Bazin, Marc, Bunnage, Mark E, Calabrese, Andrew, Cox, Mark, Fancy, Sally-Ann, Farrant, Elizabeth, Pearce, David W, Perez, Manuel, Hitzel, Laure and Peakman, Torren (2012) Lead diversification 2: application to P38, gMTP and lead compounds. Bioorganic and Medicinal Chemistry Letters, 22 (2). pp. 1255-1262. ISSN 0960-894X

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Abstract

Lead Diversification is a new technology platform developed at Pfizer for the functionalization of drug molecules using C–H activation. We describe its application to some drug programs such as P38 and gMTP and the development of some new plate based screens including a fluorination screen.

Item Type: Article
Schools and Departments: School of Life Sciences > Chemistry
Subjects: Q Science > QD Chemistry
Depositing User: Tom Gittoes
Date Deposited: 01 Jun 2015 10:01
Last Modified: 01 Jun 2015 10:01
URI: http://sro.sussex.ac.uk/id/eprint/54176
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