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A rapid route for the preparation of pyrimido[5,4-d]- and pyrido[3,2-d]oxazole

journal contribution
posted on 2023-06-08, 20:44 authored by Lucas Lemaire, Natascha Leleu-Chavain, Aurélien Tourteau, Alaa Abdul-Sada, John SpencerJohn Spencer, Régis Millet
Starting from a 5-amino-2-phenyloxazole-4-carbonitrile building block 3, obtained by reaction of benzoyl chloride (1) and aminomalononitrile p-toluenesulfonate (2), a large range of molecules were synthesized in one or two steps. A total of seven pyrimido[5,4-d]oxazoles 5(a–d)–8 and four pyrido[3,2-d]oxazoles 9–12 have been synthesized. Moreover, synthetic procedures have been adapted to overcome the instability of the oxazole ring.

History

Publication status

  • Published

Journal

Tetrahedron Letters

ISSN

0040-4039

Publisher

Elsevier

Issue

19

Volume

56

Page range

2448-2450

Department affiliated with

  • Chemistry Publications

Full text available

  • No

Peer reviewed?

  • Yes

Legacy Posted Date

2015-05-15

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