A rapid route for the preparation of pyrimido[5,4-d]- and pyrido[3,2-d]oxazole

Lemaire, Lucas, Leleu-Chavain, Natascha, Tourteau, Aurélien, Abdul-Sada, Alaa, Spencer, John and Millet, Régis (2015) A rapid route for the preparation of pyrimido[5,4-d]- and pyrido[3,2-d]oxazole. Tetrahedron Letters, 56 (19). pp. 2448-2450. ISSN 0040-4039

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Abstract

Starting from a 5-amino-2-phenyloxazole-4-carbonitrile building block 3, obtained by reaction of benzoyl chloride (1) and aminomalononitrile p-toluenesulfonate (2), a large range of molecules were synthesized in one or two steps. A total of seven pyrimido[5,4-d]oxazoles 5(a–d)–8 and four
pyrido[3,2-d]oxazoles 9–12 have been synthesized. Moreover, synthetic procedures have been adapted to overcome the instability of the oxazole ring.

Item Type: Article
Schools and Departments: School of Life Sciences > Chemistry
Subjects: Q Science > QD Chemistry > QD0241 Organic chemistry
Depositing User: John Spencer
Date Deposited: 15 May 2015 09:28
Last Modified: 15 May 2015 09:28
URI: http://sro.sussex.ac.uk/id/eprint/53940
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