Neuroimaging_and_psychophysiological_investigation_of_the_link_between_anxiety_etc.pdf (1.24 MB)
Neuroimaging and psychophysiological investigation of the link between anxiety, enhanced affective reactivity and interoception in people with joint hypermobility
journal contribution
posted on 2023-06-08, 20:36 authored by Núria Mallorquí-Bagué, Sarah Garfinkel, Miriam Engels, Jessica EcclesJessica Eccles, Guillem Pailhez, Antonio Bulbena, Hugo CritchleyHugo CritchleyObjective: Anxiety is associated with increased physiological reactivity and also increased “interoceptive” sensitivity to such changes in internal bodily arousal. Joint hypermobility, an expression of a common variation in the connective tissue protein collagen, is increasingly recognized as a risk factor to anxiety and related disorders. This study explored the link between anxiety, interoceptive sensitivity and hypermobility in a sub-clinical population using neuroimaging and psychophysiological evaluation. Methods: Thirty-six healthy volunteers undertook interoceptive sensitivity tests, a clinical examination for hypermobility and completed validated questionnaire measures of state anxiety and body awareness tendency. Nineteen participants also performed an emotional processing paradigm during functional neuroimaging. Results: We confirmed a significant relationship between state anxiety score and joint hypermobility. Interoceptive sensitivity mediated the relationship between state anxiety and hypermobility. Hypermobile, compared to non-hypermobile, participants displayed heightened neural reactivity to sad and angry scenes within brain regions implicated in anxious feeling states, notably insular cortex. Conclusions: Our findings highlight the dependence of anxiety state on bodily context, and increase our understanding of the mechanisms through which vulnerability to anxiety disorders arises in people bearing a common variant of collagen.
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Publication status
- Published
File Version
- Published version
Journal
Frontiers in PsychologyISSN
1664-1078Publisher
FrontiersExternal DOI
Volume
5Page range
1-8Article number
a1162Department affiliated with
- BSMS Neuroscience Publications
Full text available
- Yes
Peer reviewed?
- Yes
Legacy Posted Date
2015-04-27First Open Access (FOA) Date
2015-04-27First Compliant Deposit (FCD) Date
2015-04-24Usage metrics
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