Archaeal replicative primases can perform translesion DNA synthesis

Jozwiakowski, Stanislaw K, Borazjani Gholami, Farimah and Doherty, Aidan J (2015) Archaeal replicative primases can perform translesion DNA synthesis. Proceedings of the National Academy of Sciences, 112 (7). E633-E638. ISSN 0027-8424

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Abstract

DNA replicases stall at lesions during replication, potentially leading to genome instability. However, cells use specialized lesion bypass polymerases to restart stalled replisomes. Although most organisms possess these damage tolerance polymerases, capable of traversing blocking DNA lesions, many appear to lack these enzymes. We have discovered that replicative primases from archaea, previously considered to be solely involved in priming replication, are also capable of performing translesion DNA synthesis. This discovery has major implications for our understanding of additional roles of DNA primases during replication and the subsequent evolution of related lesion bypass pathways in eukaryotic organisms.

Item Type: Article
Schools and Departments: School of Life Sciences > Sussex Centre for Genome Damage and Stability
Subjects: R Medicine > R Medicine (General)
Depositing User: Catrina Hey
Date Deposited: 11 Mar 2015 14:37
Last Modified: 11 Mar 2015 15:16
URI: http://sro.sussex.ac.uk/id/eprint/53335
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Project NameSussex Project NumberFunderFunder Ref
Molecular basis for repairing DNA double-strand breaks by non homologous end-joiningG0887BBSRC-BIOTECHNOLOGY & BIOLOGICAL SCIENCES RESEARCH COUNCILBB/J018643/1
UnsetUnsetMRCG080130
The role of a novel family of eukaryotic DNA polymerases in mitochondrial DNA replicationG0207BBSRC-BIOTECHNOLOGY & BIOLOGICAL SCIENCES RESEARCH COUNCILBB/H019723/1