Calcium entry into stereocilia drives adaptation of the mechanoelectrical transducer current of mammalian cochlear hair cells

Corns, Laura F, Johnson, Stuart L, Kros, Corné J and Marcotti, Walter (2014) Calcium entry into stereocilia drives adaptation of the mechanoelectrical transducer current of mammalian cochlear hair cells. Proceedings of the National Academy of Sciences, 111 (41). pp. 14918-14923. ISSN 1091-6490

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Abstract

In the inner ear, the sensory receptor cells (hair cells) signal reception of sound. They do so by converting mechanical input, due to sound waves moving the hair bundles on these cells, into electrical current through ion channels situated at the tips of the bundles. To keep the receptors operating at their maximum sensitivity, the current declines rapidly, a process known as adaptation. In nonmammalian vertebrates, Ca2+ ions entering the mechanosensitive ion channels drive adaptation, but it has been questioned whether this mechanism applies to mammals. We show that adaptation in mammalian cochlear hair cells is, as in other vertebrates, driven by Ca2+ entry, demonstrating the importance of this process as a fundamental mechanism in vertebrate hair cells.

Item Type: Article
Schools and Departments: School of Life Sciences > Neuroscience
Subjects: Q Science > QH Natural history > QH0301 Biology
Depositing User: Tom Gittoes
Date Deposited: 05 Mar 2015 11:16
Last Modified: 25 Mar 2017 17:31
URI: http://sro.sussex.ac.uk/id/eprint/53226

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